General information

Sinemet is a combination of carbidopa and levodopa applied in treatment of Parkinson's disease and Dopa-Responsive Dystonia. It prevents hypokinesia, stiffness, tremor, dysphagia, salivary discharge. Levodopa converts into dopamine owing to DOPA decarboxylase enzyme. Activation of central dopamine receptors improves the symptoms of Parkinson's disease and combination of carbidora reduces the unwanted peripheral side-effects of levodopa. Carbidopa usage increases the quantity of levodopa in the bloodstream that is available to enter the brain.

Directions

Use Sinemet Cr exactly as prescribed by your doctor. Do not take more of this drug than is recommended. Take this medication with a full glass of water with or without food at the same time every day. Your doctor may occasionally change your dose to make sure you get the best results from this medication.

Precautions

You must tell your doctor if you have had diabetes, ocular disorders (open-narrow glaucoma), atopic eczema, skin cancer, neuropsychopathy or any allergies. Carefully follow your doctor's directions about the type and amount of liquids, meals, food supplements and other medications you may safely apply simultaneously with this product. Consult your doctor in case you are pregnant (or plan to be pregnant) or breastfeeding a child.

Contraindications

This medication is contraindicated in patients that are hypersensitive to carbidopa and levodopa. It also should not be used in patients with melanoblastoma, psychosis, myocardial infarction, a history of repeated epileptic fits, diabetes, acute renal or hepatic insufficiency, bronchial asthma, pregnancy, nursing.

Possible side effect

Most common side effects associated with this drug involve erythroderma, scaly skin, urticaria, itching, and acneiform eruptions. A very serious allergic reaction is not likely to occur. This is not a complete list of all possible side effects. Others may occur in some patients and there may be some side effects not known yet. In case you have experienced any side effect not listed above, immediately notify your doctor or local poison centre.

Drug interactions

Notify you doctor about a list of additional medicines or supplements you are already taking besides this one. It is not advisable to combine the usage of this product with other drugs of similar class without your doctor’s permission. It has been reported that Sinemet interacts with a class of antidepressants used to treat depression such as monoamine oxidase inhibitors: Phenelzine (Nardil, Nardelzine), Tranylcypromine (Parnate, Jatrosom), Isocarboxazid (Marplan), Selegiline (Deprenyl, Eldepryl, Emsam); with remedies that contain iron.

Missed dose

In case you have missed to take a dose of this herbal product, take it as soon as possible. If it is near the time to take a next dose, skip taking the missed dose and maintain your ordinary dosage schedule. Never try to make up the missed dose by taking an extra one.

Overdose

f you think you overdosed the medicine, immediately contact your local poison center and notify your doctor or pharmacist. Do this even if there are no signs of discomfort or poisoning. You may need urgent medical attention. Symptoms of overdose may involve palpitations, syncope, sickness, tightness in chest, dizziness.

Storage

Store this product in a dry tight container away from sources of sunlight, heat and moisture at room temperature between 20-25 C (or 68-77 F). Do not store it in the bathroom. Keep this product out of the reach of children and pets. Do not apply any remnants of the medication after the expiry date.

Note

The information presented at the site has a general character. Note please this information cannot be used for self-treatment and self diagnosis. You should consult with your doctor or health care adviser regarding any specific instructions of your condition. The information is reliable, but we concede it could contain mistakes. We are not responsible for any direct, indirect, special or other damage caused by use of this information on the site and also for consequences of self-treatment.